Bioactive Small Molecules
Medchemexpress LLC Thymalfasin (Thymosin α1) | 62304-98-7 | 99.3% | 3108.28 | 10 MG
Thymalfasin is an immunomodulating agent that is capable of enhancing the Thl immune response. It has demonstrated efficacy in various experimental models of immune dysfunction, including infectious diseases like hepatitis (woodchuck) and influenza (mouse), and cancers such as melanoma (mouse) and colorectal carcinoma (rat), where it exhibited antitumor effects.
- Thymalfasin is an immunomodulating agent.
- It enhances the Thl immune response.
- It has shown efficacy in experimental models of immune dysfunction.
- It has demonstrated antitumor effects in cancer models.
Medchemexpress LLC Decapeptide-12 | 137665-91-9 | 99.95% | 1395.52 | 5 MG
Decapeptide-12 is a small oligopeptide that acts as a tyrosinase inhibitor, interacting with the C-terminal residue of tyrosinase. It is a competitive inhibitor of mushroom tyrosinase and increases the transcription of SIRT, reducing melanin content in melanocytes. It is utilized in research concerning melanogenesis, senescence, and inflammation.
- Acts as a tyrosinase inhibitor
- Reduces melanin content in melanocytes
- Increases transcription of SIRT
- Used for research in melanogenesis, senescence, and inflammation
- High purity of 99.95%
Medchemexpress LLC Blu2864 | 2810747-89-6 | 99.5% | 452.43 | 100 MG
BLU2864 is an orally active, highly selective, ATP-competitive PRKACA inhibitor with an IC50 of 0.3 nM for PRKACA. It exhibits anti-tumor activity and can be utilized in cancer and polycystic kidney disease research.
- Inhibits forskolin-induced in vitro cystogenesis
- Suppresses renal basal and total PKA activities
- Leads to higher urine outputs and lower kidney weights
- Reduces FLC tumor growth
Cayman Chemical ML-351, Purity: ≥98%, CAS: 847163-28-4, 25 mg
An inhibitor of human reticulocyte 15-LO-1 (IC50 = 200 nM) with >250-fold selectivity over the related enzymes 5-LO, platelet 12-LO, 15-LO-2, ovine COX-1, and human COX-2; protects against oxidative glutamate toxicity in mouse neuronal HT-22 cells and significantly reduces infarct size in an in vivo mouse model for ischemic stroke
Cayman Chemical Acriflavine Mixture, Purity: ≥95% (mixture of flavines), 5 mg
A mixture of proflavine, acriflavine, side-methylated proflavine, and side-methylated acriflavine
Medchemexpress LLC MYF-03-176 | 2857937-59-6 | 99.7% | 410.37 | 1 ML
MYF-03-176 is an orally active inhibitor of TEAD, and suppresses TEAD transcriptional activity with an IC50 of 11 nM. The IC50 values of MYF-03-176 for TEAD1, TEAD3, and TEAD4 are 47, 32, and 71 nM, respectively. MYF-03-176 inhibits hippo signaling defective malignant pleural mesothelioma (MPM) cells. MYF-03-176 shows strong antitumor efficacy in MPM mouse xenograft model.
- IC50 and target: IC50: TEAD1 (47 nM), TEAD2 (275 nM), TEAD3 (32 nM), TEAD4 (71 nM)
- Cellular effect (NCI-H226): IC50 24 nM. Antiproliferative activity against human NCI-H226 cells assessed as reduction in cell viability measured for 5 days by CellTiter-Glo assay.
Medchemexpress LLC RHI002-Me | 314261-66-0 | 98.5% | 373.49 | C18H19N3O2S2 | 25MG
RHI002-Me is a small-molecule derivative of RHI002 reported as an hRNaseH2 inhibitor for research use. It is supplied as a solid in multiple milligram quantities and as a ready-to-use 10 mM solution in DMSO, and is accompanied by analytical documents for identity and handling. Typical applications include biochemical assays and cellular studies investigating RNase H2-related pathways.
- hRNaseH2 inhibitor suitable for biochemical and cell-based research.
- Available as solid (5 mg-100 mg) and 10 mM in DMSO (1 mL).
- High purity, typically 98.5% by HPLC.
- Molecular weight 373.49 and formula C18H19N3O2S2.
- Analytical documentation available: COA, SDS, H-NMR, RP-HPLC, MS, handling instructions.
Medchemexpress LLC PROTAC BET degrader- 25mg | 3031993-61-7 | 25 MG
PROTAC BET Degrader-3 is a proteolysis-targeting chimera that links a von Hippel-Lindau (VHL) E3 ligase ligand to a BET-family ligand to induce targeted BET protein degradation. It is supplied as a light yellow solid for research use only.
- Proteolysis-targeting chimera linking VHL and BET ligands.
- Designed to induce targeted degradation of BET-family proteins in biochemical and cellular assays.
- High purity suitable for research-grade experiments.
- Available in milligram-scale quantities for early-stage research.
- Stable as a powder at -20°C; in solution, store at -80°C for extended stability.
Medchemexpress LLC Dibenzo[b,e]oxepin-11(6H)-one | 4504-87-4 | 210.23 | 5 G
Dibenzo[b,e]oxepin-11(6H)-one is a dibenzoxepinone derivative known for its significant antiparasitic activity. It is intended for research use only.
- Exhibits inhibitory effects on the motility of the nematode *Caenorhabditis elegans*
- Treatment with 1 mM can reduce worm thrashing by 80%
- Off-white to light yellow solid appearance
Cayman Chemical 2-methoxy Estrone, Purity: ≥95%, CAS: 362-08-3, 5 mg
An active metabolite of estrone; inhibits proliferation of isolated bovine brain-derived capillary endothelial cells (IC50 = 11.5 µM); increases levels of 6-keto PGF1α in HUVECs at 0.001, 0.01, and 0.1 µM; reduces ovariectomy-induced increases in serum cholesterol in rats at 0.5 mg/kg
Medchemexpress LLC Alkyne-βAG-TOCA | >98.99% | 1100.22 | 5 MG
Alkyne-βAG-TOCA is an octreotide derivative that targets somatostatin receptor type 2 (SST2). This compound is utilized for the synthesis and research of Radionuclide-Drug Conjugates (RDCs).
- Targets somatostatin receptor type 2 (SST2)
- Octreotide derivative
- Used for synthesis/research of radionuclide-drug conjugates (RDCs)
Cayman Chemical Etaqualone, Purity: ≥98%, CAS: 7432-25-9, 5 mg
An analytical reference standard categorized as a quinazolone; intended for research and forensic applications
Medchemexpress LLC BT2 5mg | 34576-94-8 | 247.10 g/mol | C9H4Cl2O2S | 5 MG
BT2 (3,6-dichloro-1-benzothiophene-2-carboxylic acid; CAS 34576-94-8) is a small-molecule inhibitor of the branched-chain α-ketoacid dehydrogenase complex kinase (BCKDC/BDK), supplied as a research-grade powder for biochemical and cell-based studies.
- Off-white to yellow powder, available as 5 MG pack
- Chemical formula C9H4Cl2O2S; molecular weight 247.10 g/mol
- Reported purity varies by supplier (examples range from ~99.8% to ≥95%)
- Storage: powder at -20°C for long-term; in solvent, -80°C up to 6 months or -20°C up to 1 month
- Soluble in DMSO; for research use only
Medchemexpress LLC BT2 10mM 1mL | 34576-94-8 | 247.10 g/mol | C9H4Cl2O2S | 1 ML
BT2 (Benzo[b]thiophene-2-carboxylic acid, 3,6-dichloro-) is a small-molecule inhibitor of branched-chain alpha-ketoacid dehydrogenase kinase (BCKDC kinase/BDK) supplied for research use. It is available as a 10 mM solution in DMSO and as a solid, and is intended for biochemical and cellular studies (not for human use).
- Chemical name: Benzo[b]thiophene-2-carboxylic acid, 3,6-dichloro-.
- Available as 10 mM solution in DMSO (1 mL) and as solid in multiple sizes.
- High reported purity (around 99%).
- Molecular weight: 247.10 g/mol; formula: C9H4Cl2O2S.
- Recommended storage: powder -20°C (up to 3 years); in solvent -80°C (up to 6 months) or -20°C (up to 1 month).
Medchemexpress LLC CBP/p300-IN-19 hydrochloride | 2592638-14-5 | 99.0% | 514.01 | 25 MG
CBP/p300-IN-19 hydrochloride is a potent and selective p300/CBP HAT inhibitor with IC50s of 1.4, 2.2, >100, >100 μM for p300-HAT, CBP-HAT, PCAF, and Myst3, respectively. It also demonstrates antitumor activity.
- Potent and selective p300/CBP HAT inhibitor
- IC50s: 1.4 μM (p300-HAT), 2.2 μM (CBP-HAT), >100 μM (PCAF), >100 μM (Myst3)
- Shows antitumor activity
- Shows antiproliferative activity with EC50s in the micromolar range for various cell lines (MCF-7, MDA-MB231, LNCaP, PC-3, PANC-1, MDA-PANC-28, Molm-13, MV4;11, RPMI-8226 cells)
- Dose-dependently inhibits the acetylation of H3K18, H3K9, and K27